1. Fifty chronic schizophrenic patients with an average duration of mental illness of over 12 years and refractory to any other treatment had been treated with fluphenazine for a period of 3 to 4 months.2. Twenty-nine patients (58%) improved and 21 (42%) remained unimproved.3. The dose of fluphenazine varied from 2.5 mg. to 20 mg. per day. When the dose of fluphenazine was raised over 10 mg. per day, 50% of patients developed extrapyramidal symptoms.4. Fluphenazine is a valuable adjunct in the total program of rehabilitation of chronic schizophrenic patients.