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FATALITIES IN PATIENTS RECEIVING CHLORPROMAZINE AND RESERPINE DURING 1956-1957 AT PILGRIM STATE HOSPITAL
M. ZLOTLOW; A. E. PAGANINI
Am J Psychiatry 1958;115:154-156.
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Abstract

1. Fatalities in the course of treatment with chlorpromazine and reserpine are much lower than with other somatic therapies.2. Cardio-vascular and respiratory fatalities seen as the main complication with other somatic therapies are not as important complications in the course of treatment with these 2 drugs.3. In patients with brain damage, asphyxia as the cause of death is due rather to a "masked fit" or "unnoticed convulsion" than to lack of cough reflex or some specific respiratory effect.4. The development and appearance of ruptered peptic ulcer or a "silent" ulcer in patients receiving ataraxics should be further investigated.5. The disappearance of the classical syndrome of "psychotic exhaustion" as a cause of death in the years of the use of ataraxics is remarkable and must be reemphasized.

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