Get Alert
Please Wait... Processing your request... Please Wait.
You must sign in to sign-up for alerts.

Please confirm that your email address is correct, so you can successfully receive this alert.

Article   |    
Am J Psychiatry 1958;115:55-59.
text A A A
PDF of the full text article.

1. Four bilaterally adrenalectomized chronic schizophrenic patients have been maintained in good physiological states for 6 years in a state hospital setting. Another patient, continuously hospitalized since 1908, died of carcinomatous spread at age 66, 5 years after the operation. A paranoid psychotic male with cancer of the prostate and metastases was discharged from the hospital 8 months after bilateral adrenalectomy.2. A generalized, non-specific psychological response to the operation was observed in all patients. For one month, bizarre behavior and preoccupations with delusional material subsided while the previously noted ambivalent tendencies emerged in sharp focus. The period of heightened ambivalence was succeeded by a phase in which 4 patients exhibited a temporary reversal of their usual clinical behavior through abandonment of reaction formations. This sequence of behavior can be reproduced by reducing the cortisone level to near threshold maintenance levels or by providing inadequate amounts of Compounds S, B or F. The sequence is seen in the ordinary clinical course of chronic schizophrenia.3. Bilateral adrenalectomy does not significantly influence the clinical course of chronic schizophrenic patients nor does the procedure followed by adequate replacement therapy interfere with the potentialities for remissive or reversible states.4. This study does not differentiate patients for whom certain biological factors are etiologically significant from those for whom psychological events are crucial.5. The hypothesis: adrenocortical activities are significant etiologically in some schizophrenic patients, is not supported by these observations.6. The therapeutic efficacy of various and varying combinations of adrenosteroids was not observed.

Abstract Teaser
Figures in this Article

Your Session has timed out. Please sign back in to continue.
Sign In Your Session has timed out. Please sign back in to continue.
Sign In to Access Full Content
Sign in via Athens (What is this?)
Athens is a service for single sign-on which enables access to all of an institution's subscriptions on- or off-site.
Not a subscriber?

Subscribe Now/Learn More

PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development.

Need more help? PsychiatryOnline Customer Service may be reached by emailing PsychiatryOnline@psych.org or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.).




CME Activity

There is currently no quiz available for this resource. Please click here to go to the CME page to find another.
Submit a Comments
Please read the other comments before you post yours. Contributors must reveal any conflict of interest.
Comments are moderated and will appear on the site at the discertion of APA editorial staff.

* = Required Field
(if multiple authors, separate names by comma)
Example: John Doe

Web of Science® Times Cited: 7

Related Content
Manual of Clinical Psychopharmacology, 7th Edition > Chapter 1.  >
Manual of Clinical Psychopharmacology, 7th Edition > Chapter 2.  >
Manual of Clinical Psychopharmacology, 7th Edition > Chapter 9.  >
The American Psychiatric Publishing Textbook of Psychiatry, 5th Edition > Chapter 6.  >
The American Psychiatric Publishing Textbook of Psychiatry, 5th Edition > Chapter 10.  >
Topic Collections
Psychiatric News
Read more at Psychiatric News >>
APA Guidelines