1. In 7 of the 8 patients ACE in the dosage given did not obviate the need for sedation.2. In this series, ACE failed to decrease significantly the morbidity.3. ACE in large doses should be considered as a means of sedation in an alcoholic with cirrhosis in whom barbiturates are poorly tolerated.4. The administration of ACE to chronic alcoholics failed to alter their drinking pattern after they recovered from the delirium.