The use of demerol hydrochloride in 22 cases receiving artificial fever therapy in the Kettering hypertherm is reported. This represented a total of 165 treatments. The youngest patient was seventeen years and the oldest was sixty-five years of age.Treatments were usually given at weekly intervals with the temperature maintained between 105 and 107 degrees Fahrenheit for three to five hours.In 5 cases there was opportunity to compare demerol with the use of other drugs. In all such clinical comparisons demerol was found to be superior from a standpoint of management, safety and comfort of the patient. [See table In Source PDF].