1. Fifty-six patients were treated with amphetamine sulfate during the early post-intoxication period of the acute alcoholic cycle. The cycle was interrupted in 49 cases, with 7 patients failing to respond satisfactorily. The cycle was not interrupted in the control group treated with placebos.2. It was found that physical and mental "hangover effects" were markedly reduced by amphetamine sulfate in doses of 10 milligrams.3. A marked improvement in awareness, sensory perception and activity drive was observed soon after treatment.4. Mood and rapport were improved, patients demonstrating greater cooperation, increased accessibility and decreased negativism, thus facilitating the initiation of a rehabilitative program.