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BRAIN LESIONS ASSOCIATED WITH EXPERIMENTAL "EPILEPTIFORM" SEIZURES IN THE MONKEY
S. EUGENE BARRERA; LENORE M. KOPELOFF; NICHOLAS KOPELOFF
Am J Psychiatry 1944;100:727-737.
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The Department of Research Psychiatry and the Department of Bacteriology, New York State Psychiatric Institute and Hospital, New York, N. Y., Professor of Neurology and Psychiatry, Albany Medical College, and Neurologist and Psychiatrist-in-Chief, Albany Hospital, Albany, N. Y.

The Department of Research Psychiatry and the Department of Bacteriology, New York State Psychiatric Institute and Hospital, New York, N. Y.

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Abstract

By means of a single application to the cerebral motor cortex of certain chemical and immunologic agents, it has been possible to produce convulsive seizures in the rhesus monkey. Of more significance than the acute manifestations observed, was the state of chronic convulsive reactivity induced.A histopathologic examination of monkeys exhibiting recurrent convulsive seizures indicated a pathologic process which was essentially that of a chronic progressive meningocortical cicatrix. However, a similar type of lesion was produced by control preparations which failed to induce convulsive seizures at any time during a long observation period.From this study it must be concluded that the pathologic changes observed were insufficient to account by themselves for the convulsive manifestations.

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