1. A report is given of 102 patients treated with picrotoxin as convulsant. 64 of the patients received a combination of picrotoxin with metrazol.2. The combined treatment reduces nausea and vomiting to a minimum. Multiple convulsions occurred in two instances only. Terror was absent, and the paroxysm was induced in a conveniently short time.3. Complications were approximately the same in type and frequency as when picrotoxin or metrazol alone were used.