Get Alert
Please Wait... Processing your request... Please Wait.
You must sign in to sign-up for alerts.

Please confirm that your email address is correct, so you can successfully receive this alert.

Article   |    
Am J Psychiatry 1940;96:1389-1405.
View Author and Article Information

Department of Medical Research, Banting Institute, University of Toronto and Research Fellows of the Neuro-Psychiatric Institute of the Hartford Retreat.

Department of Medical Research, Banting Institute, University of Toronto.

text A A A
PDF of the full text article.

(1) The bioelectric potentials from the brain of the rabbit have been studied during metrazol and insulin shock. Insulin, administered subcutaneously, causes a marked increase in the slow wave activity during the coma stage. Cortical potentials during the convulsions are masked by the potential artefacts caused by the violent movements. Except for a few cases of localized spike potentials recorded from the cortex during the pre-convulsive stage, no characteristic cortical potentials are seen immediately preceding the convulsion.(2) The potentials recorded from the cortex following a shock injection of metrazol may be divided into four phases. These phases are correlated with the various stages of the physical shock.(3) Thalamus, midbrain and cerebellum show abnormal electrical activity during metrazol shock.(4) Sections at various levels in the central nervous system show that the electrical response in the cortex due to the action of metrazol, is not primarily dependent on the severed pathways. Characteristic shock potential sequences may even be recorded from small areas of neurologically isolated cortical tissue. The physical shock, on the other hand, is altered profoundly by these neurological sections.(5) Minute quantities of metrazol, applied locally to discrete areas of the cortex of the rabbit, initiate a bioelectric response which, although much more localized, resembles closely that seen following intravenous injection. This activity may spread to other cortical or even sub-cortical areas, presumably by facilitation.(6) An attempt is made to explain something of the action of metrazol on the brain, on the basis of what is already known regarding the effects of faradic stimulation of the cortex.

Abstract Teaser
Figures in this Article


insulin coma
Your Session has timed out. Please sign back in to continue.
Sign In Your Session has timed out. Please sign back in to continue.
Sign In to Access Full Content
Sign in via Athens (What is this?)
Athens is a service for single sign-on which enables access to all of an institution's subscriptions on- or off-site.
Not a subscriber?

Subscribe Now/Learn More

PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development.

Need more help? PsychiatryOnline Customer Service may be reached by emailing PsychiatryOnline@psych.org or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.).




CME Activity

There is currently no quiz available for this resource. Please click here to go to the CME page to find another.
Submit a Comments
Please read the other comments before you post yours. Contributors must reveal any conflict of interest.
Comments are moderated and will appear on the site at the discertion of APA editorial staff.

* = Required Field
(if multiple authors, separate names by comma)
Example: John Doe

Related Content
The American Psychiatric Publishing Textbook of Psychopharmacology, 4th Edition > Chapter 44.  >
Manual of Clinical Psychopharmacology, 7th Edition > Chapter 8.  >
Psychiatric News
PubMed Articles