Eighty-two reports of cases of lipodystrophy were reviewed. Fifteen patients were markedly self-conscious about changes in their appearance. In 17 cases the family or friends were worried about the patient's health. In eight, nervous or mental symptoms were rather marked. In 43 no abnormality of behavior was noted.There seemed to be no psychiatric symptom-complex common to lipodystrophy, aside from self-consciousness and the tendency to share in the alarm of friends and relatives. Psychiatric symptoms when present seemed on the whole to be psychoneurotic. No constant neurologic symptoms or signs were observed accompanying lipodystrophy.Although weakness is a usual symptom at one stage or another of lipodystrophy, no general symptom-complex or diseases can be considered closely related to it until more cases are available for study.Nervous symptoms in all cases resulting from self-consciousness over personal appearance are not constantly present. No conclusive evidence has been collected to support the theory that the integrity of the nervous system is affected by the disorder.