We agree with Kaufman and Harper’s observation and appreciate their pointing out that the results of our research appear even more striking when portrayed in terms of number needed to treat. In our study, the number needed to treat is seven when computed across all individuals regardless of their haplotype status, supporting the established effect of pharmacotherapy. However, this number varies widely depending on the individual’s haplotype. Based on their absolute risks, the number needed to treat is four for smokers with the high-risk haplotype, seven for smokers with the intermediate-risk haplotype, and >1,000 for smokers with the low-risk haplotype. We agree with Kaufman and Harper that a number needed to treat of four is an impressive finding compared with the numbers needed to treat of many existing pharmacotherapies. The wide variation between smokers with different haplotypes supports the notion that personalized smoking cessation intervention based on genotype could meaningfully increase the efficiency of such treatment.