Interpersonal psychotherapy (IPT) was officially described and “codified” in the 1970s and 1980s with the publication of what are now classic studies and a foundational book (1–3). Through decades of research, IPT has since been elevated to the anointed ranks of evidence-supported or evidence-based treatments. Therapists practicing IPT attend primarily to here-and-now issues, such as recent losses, interpersonal conflicts, role transitions (e.g., empty nesting, divorce, retirement), and interpersonal deficits (personality and communication difficulties). IPT fully respects biological, psychodynamic, and cognitive and behavioral influences and strategies. Featured techniques include education, exploration, interpretation, emotional ventilation, goal setting, and problem solving. Focusing on the psychological spaces in which most patients actually experience their problems, honoring and emphasizing the importance of the common and universal factors accounting for much of the favorable outcomes of psychotherapy, and fitting into an overall brief therapy time frame that many patients can actually accommodate, from my perspective, make IPT one of the most practical, holistic, and effective real-world psychotherapies.