Two unpublished analyses cast doubt on the validity of retrospective reports of premenstrual exacerbation in women with major depressive disorder. Kornstein et al. (4) analyzed data from a large multicenter treatment study of chronic depression in which women were asked, "Are you aware of regularly occurring worsening of your mood related to your menstrual cycle?" A subset of 97 women maintained a daily log of mood symptoms over one menstrual cycle prior to treatment. There was no association between the two types of reports: 27% of women with and 26% of women with no self-reported premenstrual exacerbation had prospectively confirmed premenstrual exacerbation on daily ratings. Harvey et al. (5) examined women in clinical trials of antidepressant efficacy. Premenstrual syndrome was reported by 18 of 27 women. When visit-to-visit changes in HAM-D scores were examined as a function of phase of the menstrual cycle at the time of rating, premenstrual exacerbation was apparent in 26% of the women. There was no association (r2=–0.002) between self-reported premenstrual syndrome and premenstrual exacerbation score.