A volume reduction in the amygdala appears to be common in two different groups of conduct-disordered adolescents. In the largest structural imaging study of conduct disorder to date, Fairchild et al. (1), in this issue of the Journal, compared 63 children with conduct disorder (early onset: N=36; adolescent onset: N=27) with 27 healthy comparison subjects on gray matter volumes in four regions of interest. Their primary finding was reduced amygdala volumes in both conduct disorder subgroups compared with volumes in healthy subjects. The adolescent-onset subgroup additionally demonstrated volume reductions in the right insula, left orbito-frontal cortex, and dorsomedial prefrontal cortex relative to comparison subjects. The early-onset subgroup, in contrast, only evidenced reduced dorsomedial gray matter volumes. Finally, within the conduct disorder group, higher scores on callous-unemotional traits were associated with a volumetric increase in the caudate nucleus; otherwise, no association was found with psychopathic-like personality. These new research findings in adolescents with conduct disorder converge with other findings in adolescents and adults that have shown both structural and functional abnormalities in the amygdala (2, 3). As such, they provide an important lifespan perspective to the adult literature on conduct disorder and add growing support for a neurodevelopmental perspective on the disorder.