In each of these cases, 5—10 mg/day of asenapine was associated with improved fluency. The most common side effect was sedation. One patient reported a 10-lb weight increase, but the other two experienced none. All patients presented to our clinic for stuttering treatment, and no formal measures of fluency were taken. These case reports suggest that asena-pine may be an effective and well-tolerated medication for the treatment of stuttering. However, research using randomized placebo-controlled trials is warranted to further investigate asenapine in stuttering.