Prescription glucocorticoids such as prednisone and methylprednisolone have been used for more than 60 years. Their immunosuppressant and anti-inflammatory properties make them useful for a variety of illnesses, including allergies, asthma, chronic obstructive pulmonary disease, arthritis, systemic lupus erythematosus (SLE), and inflammatory bowel disease, to name a few. They are also used as part of medication regimens to prevent transplant rejection. Despite their potentially lifesaving properties, glucocorticoids are associated with numerous side effects, including bone loss, glaucoma, cataracts, infection, bruising, and diabetes. With long-term use, patients taking glucocorticoids can also develop Cushingoid features, including buffalo hump, moon facies, and truncal obesity.