Some excellent contributors take a step forward in integrating knowledge about these disorders. Michael Rutter summarizes the history of the concept and the important turning points in its investigation. His contribution is brilliant and straightforward. He is particularly clear and categorical in his statements regarding the right and wrong steps, including his own, taken by scholars interested in autism over the past 65 years. Judith Miller and Sally Ozonoff share their valuable insight on controversial issues, such as diagnostic challenges, and comment on important social aspects that may affect research and funding targets, such as the "culture of Asperger's syndrome" and the positive stigma associated with this category of disorders. The chapter on incidence and prevalence, by Eric Fombonne, provides a deep and clear account of the increasing prevalence and uncertain increasing incidence of autism spectrum disorders. John Constantino starts his chapter on social impairment with a categorical, apparently naïve but highly useful and necessary statement, that should guide every description, classification, investigation, and service for individuals with autism spectrum disorders: "Relative deficiency in reciprocal social behavior is the sine qua non of all autism spectrum disorders (ASDs)" (p. 139). The selection of topics in the Target Symptoms part of the textbook is very useful for the clinician (i.e., chapters on Social Impairment, Development of Language and Communication, Disruptive Behaviors, Restricted Repetitive Behaviors, Self-Injury, Aggression and Related Problems, Associated Symptoms, Sleep Disorders, and Comorbid Disorders). Also very useful is the chapter on Complementary and Alternative Treatments by Michelle Zimmer, who gives a very comprehensive and commonsensical approach, accompanied by available evidence-based data, on how to manage the immense and extended use of complementary and alternative therapies by patients with autism spectrum disorders and their families. This chapter was a difficult undertaking and one very constructively resolved.