The study by Warner et al. in this issue (6) makes two important contributions to our understanding of the effects and potential of predeployment mental health screening. First, it is the first study to evaluate the effectiveness of predeployment screening for psychiatric disorders for a modern military combat setting, and specifically for U.S. troops in Iraq. Second, the authors show how a clear protocol can systematically link predeployment screening with care coordination, integrated from predeployment to deployment settings, to reduce significant negative mental health outcomes in deployed soldiers. As implementation of the 2006 Department of Defense policy was uneven across brigades because of their rapid deployment during the 2007 surge of forces into Iraq, the authors took the opportunity to compare the effects of two forms of predeployment mental health assessment on dysfunctional outcomes during deployment: PreDHA assessment alone versus the PreDHA plus their predeployment mental health screen operationalizing the 2006 policy criteria (3) with coordinated care during deployment. Using a cohort design, the authors compared 10,678 soldiers from three brigades screened prior to deployment with 10,353 soldiers from three brigades that were not screened prior to deployment. The authors measured outcomes during deployment in Iraq that indicated significant dysfunction: seeking mental health services for combat stress, psychiatric disorders, or suicidal ideation; being placed on occupational duty restrictions (e.g., short-term weapons restrictions); and air evacuation from theater for behavioral health problems.