Evaluation of Functionally Meaningful Measures for Clinical Trials of Cognition Enhancement in Schizophrenia

From the Semel Institute of Neuroscience and Human Behavior, UCLA, Los Angeles; VA Desert Pacific Mental Illness Research, Education, and Clinical Center, Los Angeles; SUNY Downstate Medical Center, Brooklyn, N.Y.; VISN 5 Mental Illness Research, Education, and Clinical Center, Baltimore; Northeastern Ohio Universities College of Medicine, Rootstown; GlaxoSmithKline, Research Triangle Park, N.C.; Psychiatry and Behavioral Sciences, Emory University, Atlanta; Merck, North Wales, Pa.; Sanofi-Aventis, Malvern, Pa.; Pfizer, Inc., New London, Conn.; Beth Israel Deaconess Medical Center/Harvard Medical School, Boston; Uptown Research Institute, Chicago; Collaborative Neuroscience Network, Garden Grove, Calif.; and NIMH, Bethesda, Md.

From the Semel Institute of Neuroscience and Human Behavior, UCLA, Los Angeles; VA Desert Pacific Mental Illness Research, Education, and Clinical Center, Los Angeles; SUNY Downstate Medical Center, Brooklyn, N.Y.; VISN 5 Mental Illness Research, Education, and Clinical Center, Baltimore; Northeastern Ohio Universities College of Medicine, Rootstown; GlaxoSmithKline, Research Triangle Park, N.C.; Psychiatry and Behavioral Sciences, Emory University, Atlanta; Merck, North Wales, Pa.; Sanofi-Aventis, Malvern, Pa.; Pfizer, Inc., New London, Conn.; Beth Israel Deaconess Medical Center/Harvard Medical School, Boston; Uptown Research Institute, Chicago; Collaborative Neuroscience Network, Garden Grove, Calif.; and NIMH, Bethesda, Md.

From the Semel Institute of Neuroscience and Human Behavior, UCLA, Los Angeles; VA Desert Pacific Mental Illness Research, Education, and Clinical Center, Los Angeles; SUNY Downstate Medical Center, Brooklyn, N.Y.; VISN 5 Mental Illness Research, Education, and Clinical Center, Baltimore; Northeastern Ohio Universities College of Medicine, Rootstown; GlaxoSmithKline, Research Triangle Park, N.C.; Psychiatry and Behavioral Sciences, Emory University, Atlanta; Merck, North Wales, Pa.; Sanofi-Aventis, Malvern, Pa.; Pfizer, Inc., New London, Conn.; Beth Israel Deaconess Medical Center/Harvard Medical School, Boston; Uptown Research Institute, Chicago; Collaborative Neuroscience Network, Garden Grove, Calif.; and NIMH, Bethesda, Md.

From the Semel Institute of Neuroscience and Human Behavior, UCLA, Los Angeles; VA Desert Pacific Mental Illness Research, Education, and Clinical Center, Los Angeles; SUNY Downstate Medical Center, Brooklyn, N.Y.; VISN 5 Mental Illness Research, Education, and Clinical Center, Baltimore; Northeastern Ohio Universities College of Medicine, Rootstown; GlaxoSmithKline, Research Triangle Park, N.C.; Psychiatry and Behavioral Sciences, Emory University, Atlanta; Merck, North Wales, Pa.; Sanofi-Aventis, Malvern, Pa.; Pfizer, Inc., New London, Conn.; Beth Israel Deaconess Medical Center/Harvard Medical School, Boston; Uptown Research Institute, Chicago; Collaborative Neuroscience Network, Garden Grove, Calif.; and NIMH, Bethesda, Md.

From the Semel Institute of Neuroscience and Human Behavior, UCLA, Los Angeles; VA Desert Pacific Mental Illness Research, Education, and Clinical Center, Los Angeles; SUNY Downstate Medical Center, Brooklyn, N.Y.; VISN 5 Mental Illness Research, Education, and Clinical Center, Baltimore; Northeastern Ohio Universities College of Medicine, Rootstown; GlaxoSmithKline, Research Triangle Park, N.C.; Psychiatry and Behavioral Sciences, Emory University, Atlanta; Merck, North Wales, Pa.; Sanofi-Aventis, Malvern, Pa.; Pfizer, Inc., New London, Conn.; Beth Israel Deaconess Medical Center/Harvard Medical School, Boston; Uptown Research Institute, Chicago; Collaborative Neuroscience Network, Garden Grove, Calif.; and NIMH, Bethesda, Md.

From the Semel Institute of Neuroscience and Human Behavior, UCLA, Los Angeles; VA Desert Pacific Mental Illness Research, Education, and Clinical Center, Los Angeles; SUNY Downstate Medical Center, Brooklyn, N.Y.; VISN 5 Mental Illness Research, Education, and Clinical Center, Baltimore; Northeastern Ohio Universities College of Medicine, Rootstown; GlaxoSmithKline, Research Triangle Park, N.C.; Psychiatry and Behavioral Sciences, Emory University, Atlanta; Merck, North Wales, Pa.; Sanofi-Aventis, Malvern, Pa.; Pfizer, Inc., New London, Conn.; Beth Israel Deaconess Medical Center/Harvard Medical School, Boston; Uptown Research Institute, Chicago; Collaborative Neuroscience Network, Garden Grove, Calif.; and NIMH, Bethesda, Md.

From the Semel Institute of Neuroscience and Human Behavior, UCLA, Los Angeles; VA Desert Pacific Mental Illness Research, Education, and Clinical Center, Los Angeles; SUNY Downstate Medical Center, Brooklyn, N.Y.; VISN 5 Mental Illness Research, Education, and Clinical Center, Baltimore; Northeastern Ohio Universities College of Medicine, Rootstown; GlaxoSmithKline, Research Triangle Park, N.C.; Psychiatry and Behavioral Sciences, Emory University, Atlanta; Merck, North Wales, Pa.; Sanofi-Aventis, Malvern, Pa.; Pfizer, Inc., New London, Conn.; Beth Israel Deaconess Medical Center/Harvard Medical School, Boston; Uptown Research Institute, Chicago; Collaborative Neuroscience Network, Garden Grove, Calif.; and NIMH, Bethesda, Md.

From the Semel Institute of Neuroscience and Human Behavior, UCLA, Los Angeles; VA Desert Pacific Mental Illness Research, Education, and Clinical Center, Los Angeles; SUNY Downstate Medical Center, Brooklyn, N.Y.; VISN 5 Mental Illness Research, Education, and Clinical Center, Baltimore; Northeastern Ohio Universities College of Medicine, Rootstown; GlaxoSmithKline, Research Triangle Park, N.C.; Psychiatry and Behavioral Sciences, Emory University, Atlanta; Merck, North Wales, Pa.; Sanofi-Aventis, Malvern, Pa.; Pfizer, Inc., New London, Conn.; Beth Israel Deaconess Medical Center/Harvard Medical School, Boston; Uptown Research Institute, Chicago; Collaborative Neuroscience Network, Garden Grove, Calif.; and NIMH, Bethesda, Md.

From the Semel Institute of Neuroscience and Human Behavior, UCLA, Los Angeles; VA Desert Pacific Mental Illness Research, Education, and Clinical Center, Los Angeles; SUNY Downstate Medical Center, Brooklyn, N.Y.; VISN 5 Mental Illness Research, Education, and Clinical Center, Baltimore; Northeastern Ohio Universities College of Medicine, Rootstown; GlaxoSmithKline, Research Triangle Park, N.C.; Psychiatry and Behavioral Sciences, Emory University, Atlanta; Merck, North Wales, Pa.; Sanofi-Aventis, Malvern, Pa.; Pfizer, Inc., New London, Conn.; Beth Israel Deaconess Medical Center/Harvard Medical School, Boston; Uptown Research Institute, Chicago; Collaborative Neuroscience Network, Garden Grove, Calif.; and NIMH, Bethesda, Md.

From the Semel Institute of Neuroscience and Human Behavior, UCLA, Los Angeles; VA Desert Pacific Mental Illness Research, Education, and Clinical Center, Los Angeles; SUNY Downstate Medical Center, Brooklyn, N.Y.; VISN 5 Mental Illness Research, Education, and Clinical Center, Baltimore; Northeastern Ohio Universities College of Medicine, Rootstown; GlaxoSmithKline, Research Triangle Park, N.C.; Psychiatry and Behavioral Sciences, Emory University, Atlanta; Merck, North Wales, Pa.; Sanofi-Aventis, Malvern, Pa.; Pfizer, Inc., New London, Conn.; Beth Israel Deaconess Medical Center/Harvard Medical School, Boston; Uptown Research Institute, Chicago; Collaborative Neuroscience Network, Garden Grove, Calif.; and NIMH, Bethesda, Md.

From the Semel Institute of Neuroscience and Human Behavior, UCLA, Los Angeles; VA Desert Pacific Mental Illness Research, Education, and Clinical Center, Los Angeles; SUNY Downstate Medical Center, Brooklyn, N.Y.; VISN 5 Mental Illness Research, Education, and Clinical Center, Baltimore; Northeastern Ohio Universities College of Medicine, Rootstown; GlaxoSmithKline, Research Triangle Park, N.C.; Psychiatry and Behavioral Sciences, Emory University, Atlanta; Merck, North Wales, Pa.; Sanofi-Aventis, Malvern, Pa.; Pfizer, Inc., New London, Conn.; Beth Israel Deaconess Medical Center/Harvard Medical School, Boston; Uptown Research Institute, Chicago; Collaborative Neuroscience Network, Garden Grove, Calif.; and NIMH, Bethesda, Md.

From the Semel Institute of Neuroscience and Human Behavior, UCLA, Los Angeles; VA Desert Pacific Mental Illness Research, Education, and Clinical Center, Los Angeles; SUNY Downstate Medical Center, Brooklyn, N.Y.; VISN 5 Mental Illness Research, Education, and Clinical Center, Baltimore; Northeastern Ohio Universities College of Medicine, Rootstown; GlaxoSmithKline, Research Triangle Park, N.C.; Psychiatry and Behavioral Sciences, Emory University, Atlanta; Merck, North Wales, Pa.; Sanofi-Aventis, Malvern, Pa.; Pfizer, Inc., New London, Conn.; Beth Israel Deaconess Medical Center/Harvard Medical School, Boston; Uptown Research Institute, Chicago; Collaborative Neuroscience Network, Garden Grove, Calif.; and NIMH, Bethesda, Md.

From the Semel Institute of Neuroscience and Human Behavior, UCLA, Los Angeles; VA Desert Pacific Mental Illness Research, Education, and Clinical Center, Los Angeles; SUNY Downstate Medical Center, Brooklyn, N.Y.; VISN 5 Mental Illness Research, Education, and Clinical Center, Baltimore; Northeastern Ohio Universities College of Medicine, Rootstown; GlaxoSmithKline, Research Triangle Park, N.C.; Psychiatry and Behavioral Sciences, Emory University, Atlanta; Merck, North Wales, Pa.; Sanofi-Aventis, Malvern, Pa.; Pfizer, Inc., New London, Conn.; Beth Israel Deaconess Medical Center/Harvard Medical School, Boston; Uptown Research Institute, Chicago; Collaborative Neuroscience Network, Garden Grove, Calif.; and NIMH, Bethesda, Md.

From the Semel Institute of Neuroscience and Human Behavior, UCLA, Los Angeles; VA Desert Pacific Mental Illness Research, Education, and Clinical Center, Los Angeles; SUNY Downstate Medical Center, Brooklyn, N.Y.; VISN 5 Mental Illness Research, Education, and Clinical Center, Baltimore; Northeastern Ohio Universities College of Medicine, Rootstown; GlaxoSmithKline, Research Triangle Park, N.C.; Psychiatry and Behavioral Sciences, Emory University, Atlanta; Merck, North Wales, Pa.; Sanofi-Aventis, Malvern, Pa.; Pfizer, Inc., New London, Conn.; Beth Israel Deaconess Medical Center/Harvard Medical School, Boston; Uptown Research Institute, Chicago; Collaborative Neuroscience Network, Garden Grove, Calif.; and NIMH, Bethesda, Md.