Another potential intervention to maintain adherence is the use of long-acting formulations of antipsychotics with recent-onset patients early in the course of treatment before nonadherence becomes established. Long-acting formulations eliminate the covert nonadherence that can occur with oral formulations. Knowing that patients are nonadherent allows for discussions between patients and their families and clinicians about the patient's choice to suspend medication treatment and about making appropriate plans. Long-acting formulations have advantages that may be especially relevant with recent-onset patients. Young patients frequently do not wish to have their peers know that they are receiving medication and may live in situations, such as dormitories, that limit the ability to comply with oral medications without detection. Injectable medications can enhance confidentiality, since they only have to be taken within a health facility. Because recent-onset patients tend to be responsive to monotherapy with antipsychotics, they are more likely than multiepisode patients to only require injections, without supplementation with oral medications. Of specific interest in light of the data from the Subotnik et al. study, patients who accept injections are fully adherent in contrast with the partial adherence common with oral formulations. Preliminary data for long-acting formulations of newer antipsychotics suggest promise with these strategies. Two studies (5, 6) have demonstrated that agreement to injections can be obtained with a substantial percent of recent-onset patients. Weiden et al. (6) found that medication adherence, measured by time to a 2-week medication gap, was significantly longer in subjects who were randomly assigned to receive and also accepted long-acting risperidone treatment compared with subjects receiving oral maintenance medication. However, the number of recent-onset subjects studied with long-acting antipsychotic strategies remains relatively small, and further study is clearly indicated.