Our calculations, based on the data presented in the article, are inconsistent with the aforementioned percentages. The quoted percentage is 36.1% for SAMe plus antidepressant treatment among responders, whereas the actual number of responders indicated on page 945 is 18/39, or 46.1%. Likewise, the quoted percentage for SAMe plus antidepressant treatment among patients who remitted is 25.8%, whereas the actual number of these patients cited on page 945 is 14/39, or 35.8%. Interestingly, Figure 2 appears to correspond with our calculations rather than the percentages cited in the article. We believe that 36.1% was given instead of 46.1% and 25.8% instead of 35.8%. Furthermore, we believe the alteration in these percentages would affect the number needed to treat.