0
Get Alert
Please Wait... Processing your request... Please Wait.
You must sign in to sign-up for alerts.

Please confirm that your email address is correct, so you can successfully receive this alert.

1
Letters to the Editor   |    
Response to Vedeniapin Letter
Alan S. Brown, M.D., M.P.H.
Am J Psychiatry 2010;167:1276-1276. doi:10.1176/appi.ajp.2010.10040535r
View Author and Article Information

accepted for publication in June 2010

The authors' disclosures accompany the original article.

Accepted June , 2010.

Copyright © American Psychiatric Association

text A A A

To the Editor: We appreciate the comments of Dr. Vedeniapin, which call attention to the fact that it is unlikely that a prenatal infection alone can account for the fluctuations in the clinical state of schizophrenia over the long-term course of the illness.

He also introduces a mechanism for potential effects of infection in patients with schizophrenia: the small interfering RNA-induced silencing complex. Such a mechanism may not only account for changes in the expression of the illness over time but also introduces a target to be investigated for genetic polymorphisms that may interact with infectious exposures.

It should be acknowledged, however, that while such a mechanism might relate to an infectious process in the brain of a patient with schizophrenia, it probably would not explain the effect of most prenatal infectious exposures that have been associated with schizophrenia, since, as noted in our review article, most of these infections do not appear to infect the fetal brain.

Regardless, this could represent an important new lead in the discovery of pathogenic microbes that might predispose an individual to schizophrenia.

+

References

+
+

CME Activity

There is currently no quiz available for this resource. Please click here to go to the CME page to find another.
Submit a Comments
Please read the other comments before you post yours. Contributors must reveal any conflict of interest.
Comments are moderated and will appear on the site at the discertion of APA editorial staff.

* = Required Field
(if multiple authors, separate names by comma)
Example: John Doe



Related Content
Books
Dulcan's Textbook of Child and Adolescent Psychiatry > Chapter 9.  >
Dulcan's Textbook of Child and Adolescent Psychiatry > Chapter 9.  >
Textbook of Traumatic Brain Injury, 2nd Edition > Chapter 3.  >
The American Psychiatric Publishing Textbook of Psychopharmacology, 4th Edition > Chapter 46.  >
The American Psychiatric Publishing Textbook of Psychopharmacology, 4th Edition > Chapter 2.  >
Topic Collections
Psychiatric News
APA Guidelines