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Letter to the Editor   |    
Reply to Goldberg Letter
Michael J. Ostacher, M.D., M.P.H.; Roy H. Perlis, M.D., M.Sc.
Am J Psychiatry 2010;167:869-869. doi:10.1176/appi.ajp.2010.10030367r
View Author and Article Information
Boston, Mass.

The authors disclosures accompany the original article.

Accepted April , 2010.

Copyright © American Psychiatric Association

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To the Editor: We thank Dr. Goldberg for calling our attention to the findings suggesting that switch risk is increased in patients with bipolar disorder who also have substance use disorders and are treated with antidepressants. Whether the risk we observed is specific to antidepressant-treated patients is an important issue that merits further investigation.

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