The legendary Biochemical Basis of Neuropharmacology, better known as "Cooper Bloom and Roth," served as the gateway textbook of neuroscience research for several generations of basic and clinical scientists beginning in the 1980s. Its mix of introductory information on neuroanatomy, biochemistry, and pharmacology made the book accessible to students and clinicians with diverse scientific backgrounds. Its primary emphasis was on defining the mechanisms through which psychoactive drugs work—in other words, how drugs that affect behavior affect the brain. It was also the first practical textbook to integrate fundamental neuroscience into psychiatry. It was therefore one of the first textbooks with a translational approach to neuroscience. To this day, it remains my most frequently "borrowed" textbook. My cherished copy of the seventh edition, which was signed by Bob Roth, does not leave my office, as copies of other editions have had the habit of disappearing. The fact that the eighth edition was to be its last was disquieting to those of us who have depended on it as a reference and used it heavily in teaching. For me, at least, this had been the one common book I had used for teaching of neuropharmacology and neurochemistry to undergraduates, graduate and medical students, and psychiatric residents. It is therefore with great anticipation that we welcome a new book with the same fundamental mission, written with the help of two additional neuropharmacology legends, Susan Iverson and Leslie Iverson.