Suicide tends to aggregate in families, but the influence may be transmitted indirectly through a cluster of personality traits including impulsivity, attention seeking, and hostility. McGirr et al. (p. 1124) report that the characteristics of the DSM-IV cluster B personality disorders—antisocial, borderline, histrionic, and narcissistic—were significantly associated with suicidal behavior in relatives of depressed people who committed suicide. These relatives had a higher rate of suicidal behavior than relatives of nonsuicidal depressed individuals, whose rate was higher than that for relatives of nondepressed, nonsuicidal comparison subjects. Further, the relatives’ level of cluster B traits was associated with cluster B traits in the primary subject, and the influence of personality traits on suicide risk was independent of major depression. In an editorial on p. 1087, Dr. David Brent considers the relationship between impulsive aggression and suicide.