Bilateral prefrontal lobotomy was performed on 10 chronically disturbed schizophrenics and one mentally deficient patient. Insignificant amelioration of symptoms was noted in two and no improvement in all the other patients. One patient became decidedly worse and developed convulsive seizures two months following the operation. On the basis of our experience, therefore, frontal leucotomy is not recommended as a therapeutic procedure in chronic schizophrenia.Abstract Teaser