1. Administration of benzedrine sulphate and sodium amytal on alternating days cannot be recommended as a therapeutic procedure for schizophrenia.2. While the author is not enthusiastic about results obtainable with metrazol shock therapy in schizophrenia because of the definitely temporary nature of improvement when it does occur, and the serious complications, the results obtained from the trial with benzedrine and amytal, when compared with metrazol shock, were not only considerably inferior but practically negligible.3. Intravenous injections of large doses of benzedrine sulphate (30 mg.) every other day for a month to young, physically healthy adults caused no harmful effects of permanent nature.Abstract Teaser