1. An attempt has been made to contrast the symptoms and signs observed in 10 cases of schizophrenia and in 30 cases of regression neuroses.2. All cases occurred in university students.3. The impressions resulting from a statistical study would indicate that the following symptoms and signs occurred twice as frequently in the schizophrenics as in the regression neuroses: (a) rigid personality, (b) extreme deficiency in good social attitudes, (c) narrow interests, (d) poor design for living, (e) tendency for suicidal ideas, (f) unsatisfactory school work, and (g) lack of insight.4. While no conclusions are attempted it is suggested that combinations of 3 or more of the above symptoms and signs might be regarded as suggesting a schizophrenic reaction.5. With these symptoms and signs in mind a further study is being undertaken in order to test their possible value in differential diagnosis between schizophrenia and regression neuroses.Abstract Teaser