1. We have attempted to show that the cerebrospinal pathology in epilepsy is variable.2. Dehydration is a factor in common in methods of treatment which modify the seizures in epilepsy.3. The incidence of epilepsy is low in diseases in which there is present a low blood volume or a tendency to dehydration.4. Alkalosis, edema, and decreased oxygen tension, conditions favoring convulsions are closely inter-related, as are acidosis, tissue dehydration and increased oxygen tension, conditions which decrease seizures.5. A disturbance in the vasomotor control of the cerebral vessels is suggested as the precipitating factor of the epileptic convulsion.6. A trend towards higher blood volume values was found in 78 epileptics as compared with 42 controls.7. A low blood volume was found during convulsive seizures and during fainting attacks.8. Acidosis, as is produced by ammonium nitrate therapy, is not sufficient to control seizures.Abstract Teaser