Six months later, Mr. Z was rehospitalized with new-onset auditory hallucinations (multiple voices speaking to each other and urging violence) and delusions (believing that people were tampering with his windows and eavesdropping on his conversations and that he was Jesus Christ). Aripiprazole (15 mg/day) was prescribed, with gradual symptomatic improvement, and then tapered to a lower dose (7.5 mg/day) due to tremor. The patient reported that he believed smoking cannabis helped his chronic pain but that it worsened his psychotic symptoms, such that he wanted help to stop smoking the drug. After 4 weeks, he was discharged to residential substance abuse treatment with only mild, residual psychotic symptoms and a discharge diagnosis of psychotic disorder not otherwise specified, PTSD, and cannabis dependence. At a 3-month follow-up evaluation, while still taking aripiprazole, Mr. Z remained off cannabis and free of psychotic symptoms.