To the Editor: We found that 43% of the patients who attempted suicide during the follow-up period of our study met minimum standards for adequate pharmacotherapy for depression. Therefore, we do not believe that this finding means that optimal aggressive pharmacotherapy for depression does not reduce the occurrence of suicidal acts in those with major depressive episodes. Rather, we think that it reflects the problem of undertreatment more than treatment-resistant depression contributing to suicidal behavior and, in some cases, the effect of comorbidity with axis II cluster B personality disorder. As Dr. Wright points out, our literature review supported this interpretation of our data.