One of the appeals of this book is its brevity; yet, inevitably, that is also one of its shortcomings. A description from the authors of the current controversy surrounding the use of placebos in clinical drug trials would have been welcome. I would have been interested in the authors’ opinions on some other practical, perhaps mundane, topics that are often vexing: the influence of pharmaceutical companies on research, the management of budgets, and the hiring and employment of research assistants. One of the most fruitful yet peril-laden enterprises in research is that of collaboration. How have these four researchers worked together so well to produce such a seamless piece of work? Given the obvious good sense of these researchers, I suspect that they would have some pearls to pass on in these difficult areas.