For those of us who love both medicine and psychiatry, consultation-liaison has been a great, exciting experience. For me, 20 years ago at the National Institutes of Health, doing this work was extremely interesting and stimulating in a complex research environment with patients who suffered from complex medical illness. Being helpful to patients, families, and consulting physicians while knowing that you would see the patient only once or twice required a special set of skills and was rewarding in its own right. I did not have available a textbook such as this opus of Wise and Rundell; this superb compilation of what we have learned in the last quarter-century would have been of great benefit.