The prevalence of positive blood alcohol test results or alcohol-related difficulties in patients admitted to hospital emergency services ranges widely R1581BABJJGHE–R1581BABBACBC: 10% among elderly patients R1581BABEAHFB, 50% among nonfatal automobile accident victims R1581BABJDAIC, and up to 62% for patients who have attempted suicide R1581BABHBDFF. In one California study R1581BABDGFFE, the proportion of patients admitted to emergency services who were reported as displaying positive blood alcohol levels (>1 g/liter) was 10%. In France, a study carried out at the Centre Général de Montbéliard emergency services found that 17.4% of admitted patients had positive blood alcohol test results, most of them (14.5%) ≥0.8 g/liter R1581BABCHJIJ.

However, to our knowledge, no information is available on whether the patients recorded as intoxicated at admission were moderate alcohol users who occasionally got drunk, harmful drinkers (per ICD-10 criteria), alcohol abusers (per DSM-IV criteria), or alcohol-dependent patients displaying subacute or chronic alcohol intoxication. In the Californian study R1581BABDGFFE of 91 emergency services patients with blood alcohol levels >1 g/liter, Cherpitel et al. showed that only 9% of the patients were identified by the emergency services medical staff as patients with drinking problems. Only one patient was referred for specific treatment for alcoholism. In the French study R1581BABCHJIJ, after a short stay in the emergency services of the Centre Général de Montbéliard, 50% of the patients with blood alcohol levels ≥0.8 g/liter were sent home, 28% were hospitalized, and 22% were held in police custody. Specific treatment for alcoholism was offered to 2% of these patients.

Thus, in the majority of cases, no treatment for alcohol problems was offered to emergency services patients displaying acute alcohol intoxication. There are two possible explanations for this: either harmful drinkers make up only a tiny minority of such patients (2%–10%) R1581BABDGFFE, R1581BABCHJIJ, or their identification is difficult for the practitioner (because of lack of knowledge and skill).

To further investigate patients being admitted to emergency services with acute alcohol intoxication (per DSM-IV 303.00 criteria) as determined by blood test results and the biological consequences of alcohol consumption, we set out to determine the proportion 1) of moderate drinkers and 2) of alcohol abusers (per DSM-IV 305.00 criteria) or alcohol-dependent patients (per DSM-IV 303.90 criteria) among them, using the biological markers of blood alcohol, GGT R1581BABEECBF, and CDT R1581BABDADCC levels and the standard CAGE questionnaire R1581BABIGHHE–R1581BABFAHBB.

All patients aged 16–70 years who were admitted to the 24-hour-a-day emergency services area during 2 nonconsecutive months who met the criteria for acute alcohol intoxication as a principal or additional diagnosis (per DSM-IV criteria) with blood alcohol levels >0.8 g/liter were included. In France an intoxicated person ends up in emergency services only if there is evidence of need for medical or psychiatric treatment (e.g., trauma from a fall, psychotic behavior, attempted suicide, or danger to the public). Most emergencies are addressed by general practitioners, ambulance personnel, or police officers.

Subjects were excluded from the study for any of the following: refusal to give consent, serious medical condition (e.g., alcohol-induced coma, multiple trauma, or delirium tremens but not minor trauma), attempted suicide, health disorders unrelated to alcohol, or medication that modified GGT levels. A standard CBC count and blood alcohol, GGT, and CDT levels were measured within 15 minutes of admission and installation in an emergency services ward.

Examination of the patient included recording anamnestic data (antecedents and history of illness) and a clinical examination. We then waited for the patient to recover to a condition of clear-headedness compatible with an interview (disappearance of signs of acute alcohol intoxication per DSM-IV criteria). After we fully explained the study to the patients, those who gave written informed consent to participate were included. Those who refused to give informed consent were excluded. During the study, the CAGE questionnaire was used, and social and demographic information was elicited. All the patients subsequently received the results of their blood tests, in particular the GGT and CDT levels, and a specialized consultation was offered to them.

Blood alcohol was measured by means of an automated alcohol dehydrogenase enzyme method (Beckman CX 7, Paris). GGT levels were assayed by means of an enzyme method at 37 ˚C by using a Bayer Diagnostic CHEM 1 automated analyzer (Leverrusen, Germany). Normal GGT values are <65 IU/liter R1581BABFIHHJ, R1581BABHBIEC. The sensitivity of the GGT measures ranged from 40% to 88%, and the specificity ranged from 50% to 90% R1581BABHFGDH–R1581BABFJHCB.

Normal values of serum CDT are <60 mg/liter. The serum was stored at –20°C until it was assayed. CDT was measured by means of immunonephelometric assay on the basis of microisocratic anion-exchange chromatography, as described by Schellenberg et al. R1581BABFIBIE of France. The CDT level has proved a good marker of harmful drinking; it has a sensitivity of about 82% and a specificity of about 97% R1581BABFBHDE, R1581BABDFIGG. Yersin et al. R1581BABDADCC have shown that the CDT level is a particularly sensitive marker in subjects under age 40, which age usually coincides with the clinical stage of alcohol abuse and is therefore in line with our study design.

Various studies have demonstrated the lack of any correlation between GGT and CDT levels, and the independence of these two markers R1581BABCHFIE–R1581BABCEGGB. Combining them therefore increases sensitivity (86% for determining alcohol abusers and 96% for determining alcohol-dependent patients) R1581BABEFEFH.

We used the CAGE questionnaire as a standard interview for screening alcoholism. Multiple studies have shown that the CAGE questionnaire has the advantage of being fast, simple, and inexpensive, and it performs well R1581BABIGHHE, R1581BABICABB. A survey was conducted to validate the French version of the CAGE questionnaire. The sensitivity of the test was 83%, the specificity was 96%, and the percentage of patients correctly classified was 95.5%, resulting in a prevalence rate of 9% alcoholics, revealing that the French version of the CAGE is effective with the use of two or more positive answers as evidence for alcoholism R1581BABFDFHH.

The significance threshold was set at p<0.05. According to the distribution of the variables, data were expressed as means and standard deviations or as means, medians, and ranges. Comparisons were accomplished by means of the chi-square statistic and nonparametric tests (Mann-Whitney U and Spearman’s rank correlations).

We enrolled all 178 patients who arrived at emergency services at Clermont-Ferrand University Hospital during July 1997 and March 1998 with acute alcohol intoxication. Twelve patients (6.7%) met the initial exclusion criteria; three of these refused to give consent. Thus, 166 eligible patients (93.3%) were included in the study. Most of them (N=95, 57.2%) had been admitted to emergency services between 4:00 p.m. and midnight, compared with the numbers admitted from midnight to 8:00 a.m. (N=36, 21.7%) and from 8:00 a.m. to 4:00 p.m. (N=35, 21.1%). There were 130 patients (78.3%) admitted to the medical section and 36 (21.7%) admitted to the surgical section of emergency services. Their mean age was 41.7 years (SD=11.5); 124 (74.7%) were male, and 42 (25.3%) were female. About one-half (N=87, 52.4%) lived alone, and only 44 (26.5%) were employed.

Their mean blood alcohol level was 2.41 g/liter (median=2.36, range=0.86–4.61). The highest blood alcohol levels were found in the patients admitted between 4:00 p.m. and midnight (mean=2.52 g/liter), compared with those admitted from midnight to 8:00 a.m. (mean=1.83 g/liter) and 8:00 a.m. to 4:00 p.m. (mean=2.44 g/liter). Their mean GGT level was 154 IU/liter (median=56, range=7–2,463), and their mean CDT level was 100.8 mg/liter (median=79.6, range=31.4–355.2). No significant relation was found between positive GGT (>65 IU/liter) and positive CDT (>60 mg/liter) levels (χ²=0.05, df=1, p=0.82) (r_s=0.12, N=166, t=1.56, df=164, p=0.12).

The mean CDT level was significantly higher in men (107.9 mg/liter, median=87.7, range=31.4–355.2) than in women (79.8 mg/liter, median=70.5, range=35.3–269.0) (Mann-Whitney U test: z approximation=–2.42, p=0.02). The mean blood alcohol level was also significantly higher in men (2.49 g/liter, median=2.50, range=0.86–4.61) than in women (2.15 g/liter, median=2.06, range=0.98–3.78) (Mann-Whitney U test: z approximation=–2.39, p=0.02). A significant relation was found between CDT and blood alcohol levels in men (r_s=0.24, N=124, t=2.68, df=122, p=0.01) but not in women (r_s=–0.001, N=42, t=–0.01, df=40, p=1.00). A significant relation was found between GGT and blood alcohol levels in the entire group (r_s=0.38, N=166, t=5.25, df=164, p<0.0001).

The CDT level was >60 mg/liter in 109 (65.7%) of the patients, and the GGT level was >65 IU/liter in 69 (41.6%) of the patients. Thus, 132 (79.5%) of the patients had positive GGT levels, positive CDT levels, or both (F1). The CAGE questionnaire gave positive results (yes to two or more of four questions) for 137 (82.5%) of the patients (F1). Hence, 151 (91.0%) of the patients admitted to emergency services with acute alcohol intoxication had at least positive GGT or positive CDT levels or a positive CAGE questionnaire result (F1). In other words, only 15 (9.0%) of the patients had no positive results on the measures used (GGT or CDT levels or CAGE questionnaire).

To our knowledge, no studies have been carried out in patients admitted to emergency services for drunkenness to determine how many of them are moderate drinkers with simple acute alcohol intoxication and how many are alcohol abusers or are alcohol dependent, whose drunkenness is a sign of subacute or chronic alcohol intoxication. Our results show that the proportion of alcohol abusers or alcohol-dependent patients among those admitted to emergency services for acute alcohol intoxication was about 80% (positive GGT or CDT levels) and possibly 90% (positive CAGE questionnaire results or positive GGT or CDT levels).

Although the CAGE questionnaire is effective, simple, and quick, biological markers make it easier to initiate a discussion with patients who often deny having drinking problems or are unwilling to address them. The GGT level does not increase in acute alcohol abuse but only after consumption of about 80–200 g of alcohol every day for several weeks R1581BABIJFJF. CDT levels increase at lower levels of alcohol consumption. Although, to our knowledge, no study of a large group of patients has ever defined the quantity, duration, or frequency of alcohol consumption required to raise CDT levels, it appears that positive values of serum CDT are attained only after a period of alcohol consumption of about 60 g for at least 3 weeks R1581BABBFBFF–R1581BABHEJCE. The GGT-CDT marker combination is particularly interesting because the alcohol-induced elevation of these parameters occurs by means of different mechanisms, which is why no correlation has been found between them, either in this study or in others R1581BABCEGGB, R1581BABBFBFF. Combining the GGT level with the CDT level is thus more sensitive R1581BABEFEFH and therefore a good indicator of alcoholism.

Hence, it is wrong to diagnose—or consider—most patients admitted to emergency services with high blood alcohol levels as moderate drinkers seen with acute alcohol intoxication. Therapeutic strategies for moderate drinkers who occasionally get drunk are fundamentally different from those that apply to patients with alcohol abuse or alcohol dependence. In particular, for subjects who consume alcohol at harmful levels, it is vital to intervene early to forestall alcohol dependency, with its increasingly high mortality R1581BABEGHFA–R1581BABCGFAA. The efficiency of brief interventions for heavy drinkers is well documented R1581BABFJCHF, R1581BABICJDA.

The detection and early treatment of patients with alcohol problems should be a major health care objective today. However, although severe alcohol dependency is easy to diagnose, signs of alcohol abuse can be elusive. Admission to emergency services for drunkenness should be considered an indicator of likely pathological alcohol use. Indeed, patients admitted to emergency services for other reasons often prove to have alcohol problems (e.g., ill-defined episodes of malaise, falls at home, or accidents at work).

It thus seems desirable to use the CAGE questionnaire systematically R1581BABCEGGB, R1581BABFAFAD (this could be done by physicians during clinical questioning on alcohol consumption patterns) for patients admitted to emergency services. All patients with acute alcohol intoxication or with positive CAGE questionnaire results should be systematically tested for elevated GGT and CDT levels as part of a full diagnostic examination R1581BABHDHAH.

This diagnostic approach might help correct the mistaken medical assumption that most patients with drunkenness are probably merely acutely intoxicated with alcohol. Any case of drunkenness in emergency services should be considered a clinical finding suggestive of alcohol abuse or alcohol dependency, requiring appropriate specialized examination and care, including medical psychological and social therapy.

Received Oct. 26, 1999; revisions received May 2 and July 26, 2000; accepted Aug. 10, 2000. From Medical Psychology Center B, the Biochemistry Department, the Department of Biostatistics and Medical Information Technology, and the Department of Emergency Medicine, University Medical School, Clermont-Ferrand. Address reprint requests to Dr. Schwan, Centre Médico-Psychologique-B, rue Montalembert, F-63003 Clermont-Ferrand Cedex 1, France; rschwan@chu-clermontferrand.fr (e-mail). The authors thank Drs. A. Feral, D. Boussiron, and A. LeBlanc for their work and Drs. M. Plane and E. Nigon for organizational assistance.