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The American Journal of Psychiatry, VOL. 157, No. 10
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Letter to the Editor   |   October 01, 2000 
Serotonin 2A Receptor Polymorphisms and [3H]Ketanserin Binding
PAUL J. HARRISON, D.M., M.R.C.PSYCH.
Am J Psychiatry 2000;157:1710-1711. 10.1176/appi.ajp.157.10.1710
Article
References
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To the Editor: The report by Gustavo Turecki, M.D., Ph.D., and colleagues +(1), showing higher than normal [3H]ketanserin binding in the prefrontal cortex of suicide victims, extends the evidence for an involvement of the serotonin 2A (5-HT2A) receptor in suicide and mood disorders. However, the finding of an association between the level of [3H]ketanserin binding and genetic variation of the receptor in the 22 brains studied conflicts with existing data. In two larger studies no relationship existed between prefrontal cortex [3H]ketanserin binding and either the T102C polymorphism +(2) or the linked A-1438G polymorphism +(3) (N=125 and N=122, respectively). As such, any effect of these genotypes on 5-HT2A receptor expression must be considered unproved, and since both polymorphisms are silent, their functional significance remains obscure +(4).
1 +
Turecki G, Briere R, Dewar K, Antonetti T, Lesage AD, Seguin M, Chawky N, Vanier C, Alda M, Joober R, Benkelfat C, Rouleau GA: Prediction of level of serotonin 2A receptor binding by serotonin receptor 2A genetic variation in postmortem brain samples from subjects who did or did not commit suicide. Am J Psychiatry1999; 156:1456–  1458
 
2 +
Kouzmenko AP, Hayes WL, Pereira AM, Dean B, Burnet PW, HarrisonPJ:5-HT2A receptor polymorphism and steady state receptor expression in schizophrenia (letter). Lancet 1997; 349:  1815
 
3 +
Kouzmenko AP, Scaffidi A, Pereira AM, Hayes WL, Copolov DL, Dean B: No correlation between A(-1438)G polymorphism in 5-HT2A receptor gene promoter and the density of frontal cortical 5-HT2A receptors in schizophrenia. Hum Hered  1999; 49:103–105[PubMed][CrossRef]
 
4 +
Harrison PJ, Burnet PW: The 5-HT2A (serotonin2A) receptor gene in the aetiology, pathophysiology and pharmacotherapy of schizophrenia. J Psychopharmacol  1997; 11:18–20[PubMed][CrossRef]
 
+
1 +
Turecki G, Briere R, Dewar K, Antonetti T, Lesage AD, Seguin M, Chawky N, Vanier C, Alda M, Joober R, Benkelfat C, Rouleau GA: Prediction of level of serotonin 2A receptor binding by serotonin receptor 2A genetic variation in postmortem brain samples from subjects who did or did not commit suicide. Am J Psychiatry1999; 156:1456–  1458
 
2 +
Kouzmenko AP, Hayes WL, Pereira AM, Dean B, Burnet PW, HarrisonPJ:5-HT2A receptor polymorphism and steady state receptor expression in schizophrenia (letter). Lancet 1997; 349:  1815
 
3 +
Kouzmenko AP, Scaffidi A, Pereira AM, Hayes WL, Copolov DL, Dean B: No correlation between A(-1438)G polymorphism in 5-HT2A receptor gene promoter and the density of frontal cortical 5-HT2A receptors in schizophrenia. Hum Hered  1999; 49:103–105[PubMed][CrossRef]
 
4 +
Harrison PJ, Burnet PW: The 5-HT2A (serotonin2A) receptor gene in the aetiology, pathophysiology and pharmacotherapy of schizophrenia. J Psychopharmacol  1997; 11:18–20[PubMed][CrossRef]
 
+
+

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