The work, as a compendium, was designed for use by trainees and clinicians in general medicine, psychiatry, and the other mental health disciplines. The editors added five new chapters on the neurobiology of addictive substances. These are excellent and detailed descriptions of this aspect of addiction. The editors, however, placed these chapters first in the volume. This placement certainly makes sense for the student learning about addiction but might perhaps deter the pragmatic clinician from looking further into the volume for the clinically practical knowledge that rests beyond these chapters.