First, there is a steadily growing decline in clinical research in all branches of medicine, particularly in research conducted by M.D. investigators. One recent review of the number of successfully funded new applicants to the National Institutes of Health (in all fields) indicated that the percentage of M.D.s has dropped by 30% over the recent 3-year period. Our need to recruit young investigators from the available pool of talented medical students and residents is pressing. Once recruited, they must be supported and nurtured. The enormous skills contributed by Ph.D. investigators should not be minimized. Nonetheless, M.D. investigators have much to contribute as well. Having suffered empathetically as they attempt to help people of all ages who are in physical and psychological pain, they bring passion, personal human concern, and innovative insights to the research effort. We need both perspectives—basic and clinical—to solve major medical problems. There is plenty of work for everyone. But we are losing the clinical perspective.