Address reprint requests to Dr. Tucker, Department of Psychiatry and Behavioral Sciences, University of Washington, 1959 Pacific St., Box 356560, Seattle, WA 98195. The author thanks Peter Roy-Byrne, M.D., Jurgen Unutzer, M.D., and Johan Verhulst, M.D., for their comments regarding this editorial, which is a revision of a lecture given at the Department of Psychiatry at Dartmouth Medical School on Oct. 21, 1996, on the occasion of its silver anniversary.