Evidence involving patients with chronic schizophrenia, although more indirect, also suggests equivalent dosing. Unfortunately, in controlled trials directly comparing risperidone to haloperidol, lower doses of risperidone (i.e., 1–16 mg/day) have been compared to haloperidol doses of 10–20 mg/day (8-10). This has made it virtually impossible to establish whether these two compounds may be equipotent. However, other reports involving neuroleptics in lower doses, including a meta-analysis of 22 randomized, controlled trials, have indicated that for a compound such as haloperidol, the optimal daily dose range is between 3 and 8 mg (11-13). This closely parallels the multiple fixed-dose studies with risperidone indicating that 4–8 mg/day appears to represent the optimal dose range for a similar patient population (8-10).