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The American Journal of Psychiatry, VOL. 152, No. 6

Brief Reports | June 01, 1995

Double-blind, placebo-controlled trial of methylphenidate in older, depressed, medically ill patients

Am J Psychiatry 1995;152:929-931.

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Abstract

OBJECTIVE: The authors examined the efficacy of methylphenidate in the treatment of depression in a group of older, medically ill patients. METHOD: Sixteen patients underwent an 8-day double-blind, randomized, placebo-controlled crossover trial; 13 completed the trial. RESULTS: Statistically and clinically significant treatment responses were found. CONCLUSIONS: These results support the use of methylphenidate in older, medically ill patients in whom rapid resolution of depressive symptoms is crucial.

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