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The American Journal of Psychiatry, VOL. 152, No. 3

REGULAR ARTICLES | March 01, 1995

Temporal lobe proton magnetic resonance spectroscopy of patients with first-episode psychosis

Am J Psychiatry 1995;152:444-446.

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Abstract

OBJECTIVE: The authors measured the ratio of N-acetyl aspartate (a putative neuronal marker) to creatine-phosphocreatine in patients with first-episode psychosis by using proton magnetic resonance spectroscopy (MRS). METHOD: Temporal lobe 1H MRS was performed bilaterally on 13 patients with first-episode psychosis and 15 comparison subjects. The N- acetyl aspartate/creatine-phosphocreatine and choline/creatine- phosphocreatine ratios were determined. RESULTS: The N-acetyl aspartate/creatine-phosphocreatine ratio of the psychotic patients was significantly lower than that of the comparison subjects. CONCLUSIONS: These preliminary data suggest that abnormalities in temporal lobe N- acetyl aspartate concentration are present early in psychotic illness.

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