OBJECTIVE: The authors tested the hypothesis that the regional
distribution of cerebral vasculature is anomalous in schizophrenia. METHOD:
Dynamic susceptibility contrast magnetic resonance imaging was used to
evaluate cerebral blood volume in the right and left occipital cortex,
basal ganglia, and cerebellum of 10 subjects with schizophrenia and 10
healthy comparison subjects. RESULTS: Cerebral blood volume was greater in
the schizophrenic subjects in every region studied. CONCLUSIONS: The
findings suggest an abnormality of the configuration of cerebral blood
vessels in schizophrenia.Abstract Teaser