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The American Journal of Psychiatry, VOL. 152, No. 8

Brief Reports | August 01, 1995

Further evidence of a dose-response threshold for haloperidol in psychosis

Am J Psychiatry 1995;152:1210-1212.

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Abstract

OBJECTIVE: The authors' goal was to determine whether higher doses of haloperidol improve antipsychotic response. METHOD: During a 2-week, double-blind, randomized fixed-dose study, 24 psychotic patients were given 4, 10, or 40 mg/day of haloperidol. RESULTS: No clinically relevant difference between groups in favor of the higher antipsychotic doses could be detected. CONCLUSIONS: Doses of 4 mg/day of haloperidol appear to be as effective as higher doses in the treatment of psychosis.

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