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The American Journal of Psychiatry, VOL. 151, No. 3

Brief Reports | March 01, 1994

A placebo-controlled trial of trihexyphenidyl in unmedicated patients with schizophrenia

Am J Psychiatry 1994;151:429-431.

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Abstract

Seventeen patients with schizophrenia who had been free of medication for at least 2 months entered a placebo-controlled, random-order crossover trial of 5 mg of trihexyphenidyl twice daily for 4 weeks. Ten patients completed trials of both drug and placebo. Ratings of anticholinergic symptoms and of feeling the effects of the drug, controlled for order effects, were significantly higher at week 4 of the trihexyphenidyl trial than at week 4 of the placebo trial. Measures of psychosis, negative symptoms, depression, and liking the drug did not differ between trihexyphenidyl and placebo trials.

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