OBJECTIVE: The aim of this study was to provide a comprehensive assessment of neuropsychological functioning in schizophrenia so as to evaluate hypotheses of lateralized or differential cognitive impairment in this disorder. Furthermore, the study sought to address the potentially confounding factors of medication side effects and relevant demographic variables such as age, education, gender, and handedness. METHOD: The neuropsychological functioning of 28 schizophrenic patients whose medication had been withdrawn for research purposes and 15 demographically matched normal subjects was evaluated. A comprehensive battery of tasks was used to determine whether performance patterns of schizophrenic patients were consistent with models of lateralized or localized neuropsychological impairment in schizophrenia. To facilitate comparison with results of other studies, several analytic strategies were used, including comparisons of group performance on individual tests, composite function scores, and evaluation of performance based on "clinical" criteria of impairment. RESULTS: In contrast to the normal subjects, the schizophrenic patients displayed impairment across measures of motor, sensory, and perceptual functioning, verbal and nonverbal memory, and indexes of frontal lobe functioning. This pattern of generalized dysfunction was evident regardless of the method of analysis used to assess performance. CONCLUSIONS: These findings fail to support conjectures regarding differential neurocognitive deficits in schizophrenia. However, the psychometric limitations of currently available neuropsychological measures may obscure the finding of differential impairment and must be considered in interpreting the results of this study as well as those of any investigation using such instruments.Abstract Teaser