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The American Journal of Psychiatry, VOL. 151, No. 8

Brief Reports | August 01, 1994

Amelioration of negative symptoms in schizophrenia by glycine

Am J Psychiatry 1994;151:1234-1236.

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Abstract

Phencyclidine induces a psychotomimetic state by blocking neurotransmission at N-methyl-D-aspartic acid (NMDA) receptors. In a double-blind, placebo-controlled fashion, 14 medicated patients with chronic schizophrenia were treated with glycine, a potentiator of NMDA- receptor-mediated neurotransmission. Significant improvement in negative symptoms occurred in the group given glycine but not in the group given placebo, suggesting that potentiation of NMDA-receptor- mediated neurotransmission may represent an effective treatment for neuroleptic-resistant negative symptoms in schizophrenia.

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