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The American Journal of Psychiatry, VOL. 150, No. 6

REGULAR ARTICLES | June 01, 1993

Elevated growth hormone responses to pyridostigmine in obsessive- compulsive disorder: evidence of cholinergic supersensitivity

Am J Psychiatry 1993;150:961-962.

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Abstract

The growth hormone response to the acetylcholinesterase inhibitor pyridostigmine was measured in nine normothymic outpatients who met DSM- III-R criteria for obsessive-compulsive disorder. The responses were significantly elevated when compared to those found in a healthy comparison group (N = 9). The data suggest that cholinergic supersensitivity is present in obsessive-compulsive disorder.

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