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The American Journal of Psychiatry, VOL. 150, No. 3

REGULAR ARTICLES | March 01, 1993

Correlation of acute cocaine-induced changes in local cerebral blood flow with subjective effects

Am J Psychiatry 1993;150:495-497.

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Abstract

The authors administered 48 mg of intravenous cocaine or placebo to eight abstinent cocaine users in a double-blind, crossover design and examined blood flow using single photon emission computed tomography. Cocaine produced significant decreases in frontal cortical and basal ganglia blood flow; these latter correlated negatively with increases in self-ratings of "rush" and "high." The authors conclude that these local effects are compatible with dopaminergic system involvement.

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