OBJECTIVE: The purpose of this study was to assess the efficacy of
fluoxetine, a selective serotonergic antidepressant, in the treatment of
dysthymia. METHOD: Thirty-five patients who met criteria for dysthymia, but
not major depression, began randomized, double-blind 8- week trials of
fluoxetine or placebo. RESULTS: Of 32 patients who completed the study, 10
(62.5%) of the 16 patients given fluoxetine and three (18.8%) of the 16
given placebo responded to treatment. Response was defined as 1) 50% or
greater decrease in Hamilton Rating Scale for Depression score and 2) a
score of 1 or 2 on the Clinical Global Impression (CGI) improvement
subscale. Fluoxetine subjects showed significantly greater improvement at
week 8 than placebo subjects on the Hamilton depression and CGI scales, but
not on the Hopkins Symptom Check-list (58-item) or the Cornell Dysthymia
Rating Scale. CONCLUSIONS: When compared to placebo, fluoxetine showed
short-term effectiveness in treating dysthymic symptoms.Abstract Teaser