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The American Journal of Psychiatry, VOL. 149, No. 3

REGULAR ARTICLES | March 01, 1992

Blood levels and acute response to bupropion

Am J Psychiatry 1992;149:399-400.

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Abstract

Twenty-three patients with major depressive disorder were treated with bupropion in an open-design protocol. Fifteen (65.2%) of the 23 responded with a more than 50% decrease in scores on the Beck Depression Inventory. Patients with trough blood levels of 10-29 ng/ml had a significantly better response than those with trough levels of 30 ng/ml or more. This preliminary result warrants further, double-blind evaluation.

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